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Article

Landscape of Tumor Mutation Load, Mismatch Repair Deficiency, and PD-L1 Expression in a Large Patient Cohort of Gastrointestinal Cancers.

Molecular cancer research : MCR - 1 May 2018

Salem Mohamed E, Puccini Alberto, Grothey Axel, Raghavan Derek, Goldberg Richard M, Xiu Joanne, Korn W Michael, Weinberg Benjamin A, Hwang Jimmy J, Shields Anthony F, Marshall John L, Philip Philip A, Lenz Heinz-Josef

Abstract excerpt

The efficacy of immunotherapy varies widely among different gastrointestinal cancers. Response to immune checkpoint inhibitors is shown to correlate with tumor mutation load (TML), mismatch repair deficiency (dMMR) status, and programmed cell death-ligand 1 (PD-L1) expression. Herein, we quantify TML, dMMR, and PD-L1 expression and determine their interrelationship in gastrointestinal cancers. Here, a total of...

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Identifiers

PMID: 29523759
DOI: 10.1158/1541-7786.MCR-17-0735
PMCID: PMC6833953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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