Article
O-GlcNAcylation Regulates Centrosome Behavior and Cell Polarity to Reduce Pulmonary Fibrosis and Maintain the Epithelial Phenotype.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Dec 2023
Yu Fan, Yang Song, Ni Hua, Heng Dai, Wu Xuemei, Yang Mulin, Zhang Xinming, Cao Yuxin, Pei Yandong, An Di, Li Dengwen, Liu Dayong, Liu Lin, Pan Leiting, Chen Quan, Zhu Xueliang, Zhou Jun
Abstract excerpt
O-GlcNAcylation functions as a cellular nutrient and stress sensor and participates in almost all cellular processes. However, it remains unclear whether O-GlcNAcylation plays a role in the establishment and maintenance of cell polarity, because mice lacking O-GlcNAc transferase (OGT) are embryonically lethal. Here, a mild Ogt knockout mouse model is constructed and the important role of O-GlcNAcylation in...
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