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PCM1 orchestrates centrosomal and flagellar protein transport to promote sperm maturation

6 Jun 2025

Abstract excerpt

Centriolar satellites facilitate the delivery of proteins required for centrosome assembly and function, and rely on the nucleation of the scaffold protein pericentriolar material 1 (PCM1). During sperm maturation, centrosomes undergo remodeling to facilitate neckpiece formation and flagellogenesis. However, the role and mechanism of PCM1 in centrosome remodeling and sperm maturation remain to be elucidated....

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PMID: 40481240
DOI: 10.1038/s42003-025-08319-x

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