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Article

Regulation of Oct1/Pou2f1 transcription activity by O-GlcNAcylation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2013

Kang Jinsuk, Shen Zuolian, Lim Jae-Min, Handa Hiroshi, Wells Lance, Tantin Dean

Abstract excerpt

The Oct1 transcription factor is a potent regulator of stress responses, metabolism, and tumorigenicity. Although Oct1 is regulated by phosphorylation and ubiquitination, the presence and importance of other modifications is unknown. Here we show that Oct1 is modified by O-linked β-N-acetylglucosamine (O-GlcNAc) moieties. We map two sites of O-GlcNAcylation at positions T255 and S728 within human Oct1. Under...

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Identifiers

PMID: 23580612
DOI: 10.1096/fj.12-220897
PMCID: PMC3688745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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