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Article

Kinetic-pharmacodynamic model of warfarin for prothrombin time-international normalized ratio in Japanese patients.

British journal of clinical pharmacology - 1 Mar 2024

Hirai Toshinori, Aoyama Takahiko, Tsuji Yasuhiro, Itoh Toshimasa, Matsumoto Yoshiaki, Iwamoto Takuya

Abstract excerpt

AIMS: Genotype-guided dosing algorithms can explain about half of the interindividual variability in prothrombin time-international normalized ratio (PT-INR) under warfarin treatment. This study aimed to refine a published kinetic-pharmacodynamic model and guide warfarin dosage for an optimal PT-INR based on renal function. METHODS: Using a retrospective cohort of adult patients (>20 years) who were administered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37953511
DOI: 10.1111/bcp.15967

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