Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prediction of warfarin maintenance dose in Han Chinese patients using a mechanistic model based on genetic and non-genetic factors.

Clinical pharmacokinetics - 1 Jul 2013

Lu Yuan, Yang Jinbo, Zhang Haiyan, Yang Jin

Abstract excerpt

BACKGROUND AND OBJECTIVES: Many attempts have been made to predict the warfarin maintenance dose in patients beginning warfarin therapy using a descriptive model based on multiple linear regression. Here we report the first attempt to develop a comprehensive mechanistic model integrating in vitro-in vivo extrapolation (IVIVE) with a pharmacokinetic-pharmacodynamic model to predict the warfarin maintenance dose in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticoagulants
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asian People

Share to Cytochrome P-450 CYP2C9

Share to International Normalized Ratio

Share to Models, Biological

Share to Vitamin K Epoxide Reductases

Share to Warfarin

Source

Identifiers

PMID: 23515956
DOI: 10.1007/s40262-013-0054-9

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prediction of warfarin maintenance dose in Han Chinese patients using a mechanistic model based on genetic and non-genetic factors.PMID 23515956Read ↗

Determinants of the over-anticoagulation response during warfarin initiation therapy in Asian patients based on population pharmacokinetic-pharmacodynamic analyses.Semantic proximity Read ↗

To establish a model for the prediction of initial standard and maintenance doses of warfarin for the Han Chinese population based on gene polymorphism: a multicenter study.Semantic proximity Read ↗

A pharmacometric model describing the relationship between warfarin dose and INR response with respect to variations in CYP2C9, VKORC1, and age.Semantic proximity Read ↗

Warfarin Dose Model for the Prediction of Stable Maintenance Dose in Indian Patients.Semantic proximity Read ↗

Effect of CYP2C9, VKORC1, CYP4F2 and GGCX genetic variants on warfarin maintenance dose and explicating a new pharmacogenetic algorithm in South Indian population.Semantic proximity Read ↗

Validation of VKORC1 and CYP2C9 genotypes on interindividual warfarin maintenance dose: a prospective study in Chinese patients.Semantic proximity Read ↗

A pharmacogenetics-based warfarin maintenance dosing algorithm from Northern Chinese patients.Semantic proximity Read ↗

Impact of CYP2C9*3, VKORC1-1639, CYP4F2rs2108622 genetic polymorphism and clinical factors on warfarin maintenance dose in Han-Chinese patients.Semantic proximity Read ↗

Warfarin dosing algorithm using clinical, demographic and pharmacogenetic data from Chinese patients.Semantic proximity Read ↗

Establishment of a prediction algorithm for the Honghe minority group based on warfarin maintenance dose.Semantic proximity Read ↗

Establishment of a Han Chinese-specific pharmacogenetic-guided warfarin dosing algorithm.Semantic proximity Read ↗

Kinetic-pharmacodynamic model of warfarin for prothrombin time-international normalized ratio in Japanese patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.