Article
A pharmacometric model describing the relationship between warfarin dose and INR response with respect to variations in CYP2C9, VKORC1, and age.
Clinical pharmacology and therapeutics - 1 Jun 2010
Hamberg A-K, Wadelius M, Lindh J D, Dahl M L, Padrini R, Deloukas P, Rane A, Jonsson E N
Abstract excerpt
The objective of the study was to update a previous NONMEM model to describe the relationship between warfarin dose and international normalized ratio (INR) response, to decrease the dependence of the model on pharmacokinetic (PK) data, and to improve the characterization of rare genotype combinations. The effects of age and CYP2C9 genotype on S-warfarin clearance were estimated from high-quality PK data....
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