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Article

Genotype-guided dosing of warfarin through modeling and simulation.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 15 Nov 2017

Deng Jiexin, Vozmediano Valvanera, Rodriguez Monica, Cavallari Larisa H, Schmidt Stephan

Abstract excerpt

Current genotype-guided algorithms for warfarin dosing fail to deliver optimal performance in two aspects: 1) these algorithms are not able to achieve the same level of benefits in non-white populations, since they were developed based on multivariate regression analysis with mostly European/White data and did not include genetic variants found frequently in non-white populations; 2) these algorithms do not...

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Source

Identifiers

PMID: 28502675
DOI: 10.1016/j.ejps.2017.05.017

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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