Article
Theory-based pharmacokinetics and pharmacodynamics of S- and R-warfarin and effects on international normalized ratio: influence of body size, composition and genotype in cardiac surgery patients.
British journal of clinical pharmacology - 1 Apr 2017
Xue Ling, Holford Nick, Ding Xiao-Liang, Shen Zhen-Ya, Huang Chen-Rong, Zhang Hua, Zhang Jing-Jing, Guo Zhe-Ning, Xie Cheng, Zhou Ling, Chen Zhi-Yao, Liu Lin-Sheng, Miao Li-Yan
Abstract excerpt
AIMS: The aims of this study are to apply a theory-based mechanistic model to describe the pharmacokinetics (PK) and pharmacodynamics (PD) of S- and R-warfarin. METHODS: Clinical data were obtained from 264 patients. Total concentrations for S- and R-warfarin were measured by ultra-high performance liquid tandem mass spectrometry. Genotypes were measured using pyrosequencing. A sequential population PK parameter...
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