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Article

Determinants of the over-anticoagulation response during warfarin initiation therapy in Asian patients based on population pharmacokinetic-pharmacodynamic analyses.

PloS one - 1 Jan 2014

Ohara Minami, Takahashi Harumi, Lee Ming Ta Michael, Wen Ming-Shien, Lee Tsong-Hai, Chuang Hui-Ping, Luo Chen-Hui, Arima Aki, Onozuka Akiko, Nagai Rui, Shiomi Mari, Mihara Kiyoshi, Morita Takashi, Chen Yuan-Tsong

Abstract excerpt

UNLABELLED: To clarify pharmacokinetic-pharmacodynamic (PK-PD) factors associated with the over-anticoagulation response in Asians during warfarin induction therapy, population PK-PD analyses were conducted in an attempt to predict the time-courses of the plasma S-warfarin concentration, Cp(S), and coagulation and anti-coagulation (INR) responses. In 99 Chinese patients we analyzed the relationships between dose...

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Source

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Identifiers

PMID: 25148255
DOI: 10.1371/journal.pone.0105891
PMCID: PMC4141831

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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