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Article

[Population pharmacokinetic/pharmacodynamic modeling of warfarin by nonlinear mixed effects model].

Yao xue xue bao = Acta pharmaceutica Sinica - 1 Oct 2015

Lin Rong-fang, Lin Wei-wei, Wang Chang-lian, Huang Pin-fang, Fang Su-jun

Abstract excerpt

The study aimed to establish a population pharmacokinetic/pharmacodynamic (PPK/PD) model of warfarin. PCR-RFLP technique was used to genotype the CYP2C9 and VKORC1 polymorphisms of 73 patients. RP-HPLC-UV method was used to determine the 190 plasma concentrations of warfarin. Application of NONMEM, the clinical information and 263 international normalized ratio (INR) monitoring data were used to investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26837174

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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