Article
Inter-individual differences in baseline coagulation activities and their implications for international normalized ratio control during warfarin initiation therapy.
Clinical pharmacokinetics - 1 Dec 2012
Ichimura Yosuke, Takahashi Harumi, Lee Michael T M, Shiomi Mari, Mihara Kiyoshi, Morita Takashi, Chen Yuan-Tsong, Echizen Hirotoshi
Abstract excerpt
BACKGROUND AND OBJECTIVE: Genetic polymorphisms of cytochrome P450 (CYP) 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1) and patient demographic characteristics are responsible for inter-individual differences in warfarin maintenance dosage requirements. At present, however, the factors associated with over-anticoagulation responses, especially before achieving the maintenance phase, have...
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