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Article

Population pharmacokinetics and pharmacogenomics of apixaban in Japanese adult patients with atrial fibrillation.

British journal of clinical pharmacology - 1 Jun 2018

Ueshima Satoshi, Hira Daiki, Kimura Yuuma, Fujii Ryo, Tomitsuka Chiho, Yamane Takuya, Tabuchi Yohei, Ozawa Tomoya, Itoh Hideki, Ohno Seiko, Horie Minoru, Terada Tomohiro, Katsura Toshiya

Abstract excerpt

AIMS: This study aimed to analyse the effects of genetic polymorphisms in drug transporters and metabolizing enzymes, and clinical laboratory data on the pharmacokinetic parameters of apixaban. METHODS: Data were collected from 81 Japanese patients with atrial fibrillation. Pharmacogenomic data were stratified by ABCB1, ABCG2 and CYP3A5 polymorphisms. The pharmacokinetic profile of apixaban was described by a...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29457840
DOI: 10.1111/bcp.13561
PMCID: PMC5980466

Genes

ABCG2
ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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