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Article

D-galactose causes sinoatrial node dysfunction: from phenotype to mechanism.

Aging - 9 Nov 2023

Zhang Heng, Chen Chen, Liu Yue, Chen Wei, Qi Jing, Xu Yue, Ren Lu, Yang Guanlin, Min Dongyu, Liu Zhuang, Cai Xintong, Hao Miao, Xu Guanzhen, Hou Ping

Abstract excerpt

With the population aging, age-related sinoatrial node dysfunction (SND) has been on the rise. Sinoatrial node (SAN) degeneration is an important factor for the age-related SND development. However, there is no suitable animal modeling method in this field. Here, we investigated whether D-galactose could induce SAN degeneration and explored the associated mechanism. In vivo, twelve C57BL/6 mice were divided into...

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PMID: 37950730
DOI: 10.18632/aging.205196
PMCID: PMC10683603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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