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Klotho protects against aged myocardial cells by attenuating ferroptosis

28 Mar 2023

Abstract excerpt

Klotho (KL) is a renal protein with aging-suppression properties that mediates its regulatory effect during cardiac fibroblast aging. However, to determine whether KL can protect aged myocardial cells by attenuating ferroptosis, this study aimed to investigate the protective effect of KL on aged cells and to explore its potential mechanism. Cell injury of H9C2 cells was induced with D-galactose (D-gal) and...

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PMID: 36990131
DOI: 10.1016/j.exger.2023.112157

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