Article

Garlic extract diallyl sulfide protects against dilated cardiomyopathy through inhibition of oxidative stress and apoptosis in mice

2021-03-04

Abstract excerpt

<h4>Background: </h4> Diallyl sulfide (DAS) is an active ingredient in garlic that is induced when the garlic is chopped and ground. DAS has been found to act as a competitive inhibitor of CYP2E1, which is a member of the cytochrome P450 enzyme family and catalyses the metabolism of various substrates.CYP2E1 is upregulated in multiple heart diseases and causes damage mainly through the production of ROS. In mice,...

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Literature Corpus work: bb539062-4348-53d9-ad5b-cc252f900e99
DOI: 10.21203/rs.3.rs-262132/v1

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