Article
Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron.
Virology journal - 8 Nov 2023
Schröder Simon, Richter Anja, Veith Talitha, Emanuel Jackson, Gudermann Luca, Friedmann Kirstin, Jeworowski Lara M, Mühlemann Barbara, Jones Terry C, Müller Marcel A, Corman Victor M, Drosten Christian
Abstract excerpt
BACKGROUND: Intrinsic fitness costs are likely to have guided the selection of lineage-determining mutations during emergence of variants of SARS-CoV-2. Whereas changes in receptor affinity and antibody neutralization have been thoroughly mapped for individual mutations in spike, their influence on intrinsic replicative fitness remains understudied. METHODS: We analyzed mutations in immunodominant spike epitope...
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