Evolving spike mutations in SARS-CoV-2 Omicron variants facilitate evasion from breakthrough infection-acquired antibodies

Abstract excerpt

SARS-CoV-2 inevitably evolves toward being more robust at multiplying. In the herd immunity era, mutations allowing SARS-CoV-2 to bypass the immunity acquired from vaccinations or infections may be essential in improving viral transmission fitness 1 , 2 , 3 , 4 , 5 . However, how evasion mutations drive the evolution remains to be elucidated.

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