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Article

SARS-CoV-2 evolution on a dynamic immune landscape.

Nature - 1 Mar 2025

Raharinirina N Alexia, Gubela Nils, Börnigen Daniela, Smith Maureen Rebecca, Oh Djin-Ye, Budt Matthias, Mache Christin, Schillings Claudia, Fuchs Stephan, Dürrwald Ralf, Wolff Thorsten, Hölzer Martin, Paraskevopoulou Sofia, von Kleist Max

Abstract excerpt

Since the onset of the pandemic, many SARS-CoV-2 variants have emerged, exhibiting substantial evolution in the virus' spike protein1, the main target of neutralizing antibodies2. A plausible hypothesis proposes that the virus evolves to evade antibody-mediated neutralization (vaccine- or infection-induced) to maximize its ability to infect an immunologically experienced population1,3. Because viral infection...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spike Glycoprotein, Coronavirus

Source

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Identifiers

PMID: 39880955
DOI: 10.1038/s41586-024-08477-8
PMCID: PMC11882442

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