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Article

Epistasis and background dependence in the evolution of Omicron variants of the SARS-CoV-2 spike protein.

Molecular biology and evolution - 1 May 2026

Moulana Alief, Dupic Thomas, Desai Michael M

Abstract excerpt

The rapid and repeated emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, particularly within the Omicron lineage, highlights the virus's remarkable ability to adapt under shifting immune pressures. A central molecular battleground in this evolutionary arms race is the spike receptor-binding domain, which must simultaneously maintain high affinity for the human ACE2 receptor while...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42142336
DOI: 10.1093/molbev/msag100
PMCID: PMC13179739

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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