Article

Recurrent SARS-CoV-2 spike mutations confer growth advantages to select JN.1 sublineages

2024-05-29

Abstract excerpt

The recently dominant SARS-CoV-2 Omicron JN.1 has evolved into multiple sublineages, with recurrent spike mutations R346T, F456L, and T572I, some of which exhibit growth advantages, such as KP.2. We investigated these mutations in JN.1, examining their individual and combined effects on immune evasion, ACE2 receptor affinity, and in vitro infectivity. F456L increased resistance to neutralization by human sera, inc...

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Literature Corpus work: e44b28ff-5f66-54aa-a2ac-3ed2cd7e45d6
DOI: 10.1101/2024.05.29.596362

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