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Article

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis.

Frontiers of medicine - 1 Feb 2024

Xian Weiwei, Asad Mohammad, Wu Shuai, Bai Zhixin, Li Fengjiao, Lu Junfeng, Zu Gaoyu, Brintnell Erin, Chen Hong, Mao Ying, Zhou Guomin, Liao Bo, Wu Jinsong, Wang Edwin, You Linya

Abstract excerpt

The association of neurogenesis and gliogenesis with glioma remains unclear. By conducting single-cell RNA-seq analyses on 26 gliomas, we reported their classification into primitive oligodendrocyte precursor cell (pri-OPC)-like and radial glia (RG)-like tumors and validated it in a public cohort and TCGA glioma. The RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37955814
DOI: 10.1007/s11684-023-1017-7

Genes

EGFR
LGALS3
OLIG1
PTPRZ1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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