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Spatial Transcriptomics Resolve an Emphysema-Specific Lymphoid Follicle B Cell Signature in Chronic Obstructive Pulmonary Disease

7 Nov 2023

Abstract excerpt

Abstract Rationale Within chronic obstructive pulmonary disease (COPD), emphysema is characterized by a significant yet partially understood B cell immune component. Objectives To characterize the transcriptomic signatures from lymphoid follicles (LFs) in ever-smokers without COPD and patients with COPD with varying degrees of emphysema. Methods Lung sections from 40 patients with COPD and ever-smokers were used...

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PMID: 37934672
DOI: 10.1164/rccm.202303-0507le

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