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Article

Disruption of SUV39H1 -Mediated H3K9 Methylation Sustains CAR T-cell Function

31 Oct 2023

Abstract excerpt

Suboptimal functional persistence limits the efficacy of adoptive T-cell therapies. CD28-based chimeric antigen receptors (CAR) impart potent effector function to T cells but with a limited lifespan. We show here that the genetic disruption of SUV39H1, which encodes a histone-3, lysine-9 methyl-transferase, enhances the early expansion, long-term persistence, and overall antitumor efficacy of human CAR T cells in...

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PMID: 37934007
DOI: 10.1158/2159-8290.cd-22-1319

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