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CD19-CAR T cells undergo exhaustion DNA methylation programming in patients with acute lymphoblastic leukemia

1 Nov 2021

Abstract excerpt

CD19-CAR T cell therapy has evolved into the standard of care for relapsed/refractory B cell acute lymphoblastic leukemia (ALL); however, limited persistence of the CAR T cells enables tumor relapse for many patients. To gain a deeper understanding of the molecular characteristics associated with CAR T cell differentiation, we performed longitudinal genome-wide DNA methylation profiling of CD8 + CD19-CAR T cells...

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PMID: 34852226
DOI: 10.1016/j.celrep.2021.110079

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