Article

Targeting <i>ZC3H12C</i> improves T cell persistence and antitumor function in adoptive T cell therapy

2026-05-02

Abstract excerpt

Adoptive T cell therapy (ACT) has achieved remarkable clinical responses in hematologic malignancies but remains limited by progressive T cell dysfunction under chronic antigen stimulation. Here, we identify ZC3H12C as a conserved feature of dysfunctional T cells and show that its disruption enhances the durability and antitumor activity of engineered T cells. By integrating single-cell chromatin accessibility an...

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Literature Corpus work: 91748b66-73f7-57c2-84d1-96c02d11e0b6
DOI: 10.64898/2026.04.30.721618

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