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SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors

31 Oct 2023

Abstract excerpt

Failure of adoptive T-cell therapies in patients with cancer is linked to limited T-cell expansion and persistence, even in memory-prone 41BB-(BBz)-based chimeric antigen receptor (CAR) T cells. We show here that BBz-CAR T-cell stem/memory differentiation and persistence can be enhanced through epigenetic manipulation of the histone 3 lysine 9 trimethylation (H3K9me3) pathway. Inactivation of the H3K9...

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PMID: 37934001
DOI: 10.1158/2159-8290.cd-22-1350

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