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CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

29 Jun 2022

Abstract excerpt

Tumor-infiltrating CD8 + T cells progressively lose functionality and fail to reject tumors. The underlying mechanism and re-programing induced by checkpoint blockers are incompletely understood. We show here that genetic ablation or pharmacological inhibition of histone lysine methyltransferase Suv39h1 delays tumor growth and potentiates tumor rejection by anti-PD-1. In the absence of Suv39h1, anti-PD-1 induces...

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PMID: 35768432
DOI: 10.1038/s41467-022-31504-z

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