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Article

Multi-scale characterisation of homologous recombination deficiency in breast cancer

2 Nov 2023

Abstract excerpt

BACKGROUND: Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity. Patients displaying homologous recombination deficiency can be identified using 'mutational signatures'. However, these patterns are difficult to reliably infer from exome sequencing. Additionally, as mutational signatures are a historical record of...

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PMID: 37919776
DOI: 10.1186/s13073-023-01239-7

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