Article

HRDex: a tool for deriving homologous recombination deficiency (HRD) scores from whole exome sequencing data

2022-09-12

Abstract excerpt

<h4>Background</h4> Breast and ovarian tumors in patients with biallelic BRCA1 and BRCA2 mutations either by germline mutations accompanied by allele-specific loss of heterozygosity (LOH) or truncal somatic mutations respond to PARP inhibition. The repair of double stranded DNA breaks in tumors these tumors leads to homologous recombination deficiency (HRD), which can be measured using a variety of genomic and...

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Literature Corpus work: 035051cd-7277-549d-a1d7-7b02d24e5bd9
DOI: 10.1101/2022.09.08.506670

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