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Article

Responses of cultured human keratocytes and myofibroblasts to ethyl pyruvate: a microarray analysis of gene expression.

Investigative ophthalmology & visual science - 1 Jun 2010

Harvey Stephen A K, Guerriero Emily, Charukamnoetkanok Nahthai, Piluek Jordan, Schuman Joel S, Sundarraj Nirmala

Abstract excerpt

PURPOSE: Ethyl pyruvate (EP) has pharmacologic effects that remediate cellular stress. In the organ-cultured murine lens, EP ameliorates oxidative stress, and in a rat cataract model, it attenuates cataract formation. However, corneal responses to EP have not been elucidated. In this study, the potential of EP as a therapeutic agent in corneal wound healing was determined by examining its effects on the...

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Source

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Identifiers

PMID: 20053976
DOI: 10.1167/iovs.09-4498
PMCID: PMC2891457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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