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Article

Dual function of TGFβ in lens epithelial cell fate: implications for secondary cataract

17 Feb 2017

Abstract excerpt

The most common vision-disrupting complication of cataract surgery is posterior capsule opacification (PCO; secondary cataract). PCO is caused by residual lens cells undergoing one of two very different cell fates: either transdifferentiating into myofibroblasts or maturing into lens fiber cells. Although TGFβ has been strongly implicated in lens cell fibrosis, the factors responsible for the latter process have...

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PMID: 28209733
DOI: 10.1091/mbc.e16-12-0865

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