RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus.

doi:10.1038/s41590-020-00833-w

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Article

RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus.

Nature immunology - 1 Feb 2021

Ferreira Ana C F, Szeto Aydan C H, Heycock Morgan W D, Clark Paula A, Walker Jennifer A, Crisp Alastair, Barlow Jillian L, Kitching Sophie, Lim Alfred, Gogoi Mayuri, Berks Richard, Daly Maria, Jolin Helen E, McKenzie Andrew N J

Abstract excerpt

Type 2 innate lymphoid cells (ILC2) contribute to immune homeostasis, protective immunity and tissue repair. Here we demonstrate that functional ILC2 cells can arise in the embryonic thymus from shared T cell precursors, preceding the emergence of CD4+CD8+ (double-positive) T cells. Thymic ILC2 cells migrated to mucosal tissues, with colonization of the intestinal lamina propria. Expression of the transcription...

Topics

Animals
Basic-Leucine Zipper Transcription Factors
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Differentiation
Cell Lineage
Cell Movement
Cells, Cultured
Coculture Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gene Expression Regulation, Developmental

Immunity, Innate

Inhibitor of Differentiation Protein 2

Male

Mice

Mice, Inbred C57BL

Mice, Knockout

Nuclear Receptor Subfamily 1, Group F, Member 1

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Identifiers

PMID: 33432227
DOI: 10.1038/s41590-020-00833-w
PMCID: PMC7116838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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