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Article

RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus.

Nature immunology - 1 Feb 2021

Ferreira Ana C F, Szeto Aydan C H, Heycock Morgan W D, Clark Paula A, Walker Jennifer A, Crisp Alastair, Barlow Jillian L, Kitching Sophie, Lim Alfred, Gogoi Mayuri, Berks Richard, Daly Maria, Jolin Helen E, McKenzie Andrew N J

Abstract excerpt

Type 2 innate lymphoid cells (ILC2) contribute to immune homeostasis, protective immunity and tissue repair. Here we demonstrate that functional ILC2 cells can arise in the embryonic thymus from shared T cell precursors, preceding the emergence of CD4+CD8+ (double-positive) T cells. Thymic ILC2 cells migrated to mucosal tissues, with colonization of the intestinal lamina propria. Expression of the transcription...

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Share to Basic-Leucine Zipper Transcription Factors
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Coculture Techniques

Share to Nuclear Receptor Subfamily 1, Group F, Member 1

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Share to Thymocytes

Share to Thymus Gland

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Identifiers

PMID: 33432227
DOI: 10.1038/s41590-020-00833-w
PMCID: PMC7116838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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