Article

Therapeutic Potential of AIM2 in Rheumatoid Arthritis: Evidence from Multi-Omics and Preclinical Models

2025-07-30

Abstract excerpt

<title>Abstract</title> <p>Objective Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by synovial inflammation and joint destruction. This study aimed to elucidate the pathogenic role of the cytosolic DNA sensor AIM2 in RA, focusing on its expression patterns, functional mechanisms in synovial fibroblasts (FLS) and macrophages, and therapeutic potential in preclinical models. Methods Multi...

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Literature Corpus work: 1d08b2df-07e4-5583-9246-2ac604c23996
DOI: 10.21203/rs.3.rs-7223540/v1

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