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Article

The role of AIM2 in inflammation and tumors

12 Nov 2024

Abstract excerpt

Absent in melanoma 2 (AIM2) serves as an intracellular nucleic acid sensor that predominantly detects double-stranded DNA (dsDNA) within the cells. This detection initiates the assembly of inflammasome and activates the inflammasome signaling cascade, resulting in the production of inflammatory mediators and the cleavage of Gasdermins. Consequently, these processes culminate in inflammatory responses and...

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PMID: 39600708
DOI: 10.3389/fimmu.2024.1466440

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