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Article

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors.

The Journal of experimental medicine - 22 Oct 2012

Brunette Rebecca L, Young Janet M, Whitley Deborah G, Brodsky Igor E, Malik Harmit S, Stetson Daniel B

Abstract excerpt

Innate immune detection of nucleic acids is important for initiation of antiviral responses. Detection of intracellular DNA activates STING-dependent type I interferons (IFNs) and the ASC-dependent inflammasome. Certain members of the AIM2-like receptor (ALR) gene family contribute to each of these pathways, but most ALRs remain uncharacterized. Here, we identify five novel murine ALRs and perform a phylogenetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23045604
DOI: 10.1084/jem.20121960
PMCID: PMC3478938

Genes

AIM2

Provenance

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