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Article

TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2

1 Oct 2023

Abstract excerpt

Ubiquitination is an important protein modification that regulates diverse biological processes, including CD4 + T cell differentiation and functions. However, the function of most E3 ubiquitin ligases in CD4 + T cell differentiation and CD4 + T cell-mediated pathological diseases remains unclear. In this study, we find that tripartite motif-containing motif 11 (TRIM11) specifically negatively regulates...

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PMID: 37804507
DOI: 10.1016/j.celrep.2023.113231

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