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Article

TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function.

The Journal of biological chemistry - 10 Aug 2018

Cheng Qingwen, Danao Jean, Talreja Santosh, Wen Paul, Yin Jun, Sun Ning, Li Chi-Ming, Chui Danny, Tran David, Koirala Samir, Chen Hang, Foltz Ian N, Wang Songli, Sambashivan Shilpa

Abstract excerpt

Triggering receptor expressed on myeloid cells 2 (TREM2) is an orphan immune receptor expressed on cells of myeloid lineage such as macrophages and microglia. The rare variant R47H TREM2 is associated with an increased risk for Alzheimer's disease, supporting the hypothesis that TREM2 loss of function may exacerbate disease progression. However, a complete knockout of the TREM2 gene in different genetic models of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29599291
DOI: 10.1074/jbc.RA118.001848
PMCID: PMC6093249

Genes

TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function.PMID 29599291Read ↗

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