Article
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.
Cell stem cell - 2 Nov 2023
Chen Chun-Wei, Zhang Linda, Dutta Ravi, Niroula Abhishek, Miller Peter G, Gibson Christopher J, Bick Alexander G, Reyes Jaime M, Lee Yi-Tang, Tovy Ayala, Gu Tianpeng, Waldvogel Sarah, Chen Yi-Hung, Venters Bryan J, Estève Pierre-Olivier, Pradhan Sriharsa, Keogh Michael-Christopher, Natarajan Pradeep, Takahashi Koichi, Sperling Adam S, Goodell Margaret A
Abstract excerpt
Somatic mutations accumulate in all cells with age and can confer a selective advantage, leading to clonal expansion over time. In hematopoietic cells, mutations in a subset of genes regulating DNA repair or epigenetics frequently lead to clonal hematopoiesis (CH). Here, we describe the context and mechanisms that lead to enrichment of hematopoietic stem cells (HSCs) with mutations in SRCAP, which encodes a...
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