Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway.

doi:10.1038/s41467-019-13542-2

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Article

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway.

Nature communications - 11 Dec 2019

Chen Sisi, Wang Qiang, Yu Hao, Capitano Maegan L, Vemula Sasidhar, Nabinger Sarah C, Gao Rui, Yao Chonghua, Kobayashi Michihiro, Geng Zhuangzhuang, Fahey Aidan, Henley Danielle, Liu Stephen Z, Barajas Sergio, Cai Wenjie, Wolf Eric R, Ramdas Baskar, Cai Zhigang, Gao Hongyu, Luo Na, Sun Yang, Wong Terrence N, Link Daniel C, Liu Yunlong, Boswell H Scott, Mayo Lindsey D, Huang Gang, Kapur Reuben, Yoder Mervin C, Broxmeyer Hal E, Gao Zhonghua, Liu Yan

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) increases with age and is associated with increased risks of hematological malignancies. While TP53 mutations have been identified in CHIP, the molecular mechanisms by which mutant p53 promotes hematopoietic stem and progenitor cell (HSPC) expansion are largely unknown. Here we discover that mutant p53 confers a competitive advantage to HSPCs following...

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Identifiers

PMID: 31827082
DOI: 10.1038/s41467-019-13542-2
PMCID: PMC6906427

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