Article

The Clonal Hematopoiesis-associated Gene <i>Srcap</i> Plays an Essential Role in Hematopoiesis

2024-08-19

Abstract excerpt

Somatic mutations arising in hematopoietic stem cells (HSCs) may provide the latter with a fitness advantage, allowing the mutant HSC to clonally expand. Such mutations have been recurrently identified in the chromatin modifier, SRCAP , in both non-malignant and leukemic clones, suggesting that this gene plays a significant role in hematopoiesis. We generated a conditional Srcap loss of function murine model and...

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Literature Corpus work: 8be69a13-6126-538a-b682-79331814c3be
DOI: 10.1101/2024.08.16.607812

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