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Article

TRPS1 drives heterochromatic origin refiring and cancer genome evolution

1 Mar 2021

Abstract excerpt

Exploitation of naturally occurring genetic mutations could empower the discovery of novel aspects of established cancer genes. We report here that TRPS1, a gene linked to the tricho-rhino-phalangeal syndrome (TRPS) and recently identified as a potential breast cancer driver, promotes breast carcinogenesis through regulating replication. Epigenomic decomposition of TRPS1 landscape reveals nearly half of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33691114
DOI: 10.1016/j.celrep.2021.108814

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