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Article

Gain-of-Function p53 Mutation Acts as a Genetic Switch for TGFβ Signaling-Induced Epithelial-to-Mesenchymal Transition in Intestinal Tumors.

Cancer research - 2 Jan 2024

Wang Dong, Nakayama Mizuho, Hong Chang Pyo, Oshima Hiroko, Oshima Masanobu

Abstract excerpt

Signaling by TGFβ family cytokines plays a tumor-suppressive role by inducing cell differentiation, while it promotes malignant progression through epithelial-to-mesenchymal transition (EMT). Identification of the mechanisms regulating the switch from tumor suppression to tumor promotion could identify strategies for cancer prevention and treatment. To identify the key genetic alterations that determine the...

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Identifiers

PMID: 37851521
DOI: 10.1158/0008-5472.CAN-23-1490
PMCID: PMC10758690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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