Article
Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation.
Oncogene - 19 Oct 2017
Nakayama M, Sakai E, Echizen K, Yamada Y, Oshima H, Han T-S, Ohki R, Fujii S, Ochiai A, Robine S, Voon D C, Tanaka T, Taketo M M, Oshima M
Abstract excerpt
Tumor suppressor TP53 is frequently mutated in colorectal cancer (CRC), and most mutations are missense type. Although gain-of-functions by mutant p53 have been demonstrated experimentally, the precise mechanism for malignant progression in in vivo tumors remains unsolved. We generated ApcΔ716 Trp53LSL•R270H villin-CreER compound mice, in which mutant p53R270H was expressed in the intestinal epithelia upon...
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