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Article

Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties.

Nature communications - 11 May 2020

Nakayama Mizuho, Hong Chang Pyo, Oshima Hiroko, Sakai Eri, Kim Seong-Jin, Oshima Masanobu

Abstract excerpt

Missense-type mutant p53 plays a tumor-promoting role through gain-of-function (GOF) mechanism. In addition, the loss of wild-type TP53 through loss of heterozygosity (LOH) is widely found in cancer cells. However, malignant progression induced by cooperation of TP53 GOF mutation and LOH remains poorly understood. Here, we show that mouse intestinal tumors carrying Trp53 GOF mutation with LOH (AKTPM/LOH) are...

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Identifiers

PMID: 32393735
DOI: 10.1038/s41467-020-16245-1
PMCID: PMC7214469

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