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Article

Sensitivity towards HDAC inhibition is associated with RTK/MAPK pathway activation in gastric cancer.

EMBO molecular medicine - 10 Oct 2022

Seidlitz Therese, Schmäche Tim, Garcίa Fernando, Lee Joon Ho, Qin Nan, Kochall Susan, Fohgrub Juliane, Pauck David, Rothe Alexander, Koo Bon-Kyoung, Weitz Jürgen, Remke Marc, Muñoz Javier, Stange Daniel E

Abstract excerpt

Gastric cancer ranks the fifth most common and third leading cause of cancer-related deaths worldwide. Alterations in the RTK/MAPK, WNT, cell adhesion, TP53, TGFβ, NOTCH, and NFκB signaling pathways could be identified as main oncogenic drivers. A combination of altered pathways can be associated with molecular subtypes of gastric cancer. In order to generate model systems to study the impact of different pathway...

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Identifiers

PMID: 35993110
DOI: 10.15252/emmm.202215705
PMCID: PMC9549728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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