Article

Oncogene-induced senescence and senescence-associated secretory phenotype (SASP) determine the efficacy of palbociclib in PIK3CA mutated colorectal cancer

2024-11-18

Abstract excerpt

<h4>ABSTRACT</h4> Palbociclib is an excellent CDK4/6 inhibitor, but its clinical application is mainly limited to the treatment of advanced ER + /HR + and HER2 − breast cancer. Its efficacy in colorectal cancer (CRC) is evaluated in multiple trials and so far remains undetermined. We found that the PIK3CA-mutant CRC cells were insensitive to palbociclib treatment compared with the PIK3CA wild-type counterparts...

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Literature Corpus work: 7f18b378-cb4e-5418-a488-e4b8fdf92b14
DOI: 10.1101/2024.11.15.623304

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Oncogene-induced senescence and senescence-associated secretory phenotype (SASP) determine the efficacy of palbociclib in PIK3CA mutated colorectal cancerDOI 10.1101/2024.11.15.623304Read

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