Article

PRMT1-Catalyzed NUSAP1 Methylation Enhances Notch2 Signaling and 5-FU Resistance in Gastric Cancer

2025-02-03

Abstract excerpt

<title>Abstract</title> <p>5-Fluorouracil (5-FU) resistance remains a significant challenge in the treatment of gastric cancer, limiting its clinical efficacy. Our study identifies NUSAP1, a nucleolar and spindle-associated protein, as a key driver of 5-FU resistance in gastric cancer. Proteomic analyses of 5-FU-resistant gastric cancer cell lines revealed that NUSAP1 is significantly upregulated, and functional...

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Literature Corpus work: d009b339-f317-5532-8ad8-4db1592b8b4f
DOI: 10.21203/rs.3.rs-5767689/v1

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