Article
α-Tomatine Inhibits Proliferation, Metastasis, Drug Resistance and Immune Infiltration Through the PI3K-AKT-MAPK Axis in Gastric Cancer
2020-08-26
Abstract excerpt
<h4>Background: </h4> α-Tomatine, a naturally existing steroidal glycoalkaloid in immature green tomatoes, had anticarcinogenic performances in various types of cancer cells. Within this study, we aimed to investigate the efficacy and potential molecular mechanism of α-tomatine in gastric cancer (GC) and the association with immune infiltration and prognosis. <h4>Methods: </h4>: We used human GC cells MGC803, BGC8...
Topics
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- Biological and pharmacological studies of plants
- Calpain Protease Function and Regulation
- Cancer-related molecular mechanisms research
- Flavonoids in Medical Research
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Plant biochemistry and biosynthesis
- Plant Molecular Biology Research
Identifiers and source
- Literature Corpus work
- 40e1c3b4-fe23-57f0-a86a-1e80a2908175
- DOI
- 10.21203/rs.3.rs-53224/v1
