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B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus

1 Oct 2023

Abstract excerpt

OBJECTIVE: B cell function and autoantibodies are important in SLE pathogenesis. In this work, we aimed to investigate the impact of cumulative SLE B cell genetics on SLE subphenotype and autoantibody profile. METHODS: Female patients with SLE (n=1248) and healthy controls (n=400) were genotyped using Illumina's Global Screening Array. Two polygenic risk scores (PRSs), one representing B cell genes and the other...

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PMID: 37844960
DOI: 10.1136/lupus-2023-000926

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